Christina Applegate says SAG Awards will likely be her last awards show appearance as an actor

Christina Applegate has said her upcoming appearance at the SAG Awards will likely be her last appearance at an awards show as an actress.

Speaking to The Los Angeles Times, the Dead To Me actress gave the sad news, which comes as she finds it more difficult to work while living with multiple sclerosis.

"It's my last awards show as an actor probably, so it's kind of a big deal," the 51-year-old said.

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"Right now, I couldn't imagine getting up at 5 am and spending 12 to 14 hours on a set; I don't have that in me at this moment," she added.

Applegate was diagnosed with MS in 2021 and announced it to her fans that year. At the time, she was filming Dead To Me's third and final season, and had to postpone filming while she dealt with pain and limitations from the condition.

This year the actress is nominated for Outstanding Performance by a Female Actor in a Comedy Series for her role as Jen Harding in Dead To Me. The nomination marks her sixth-ever SAG nomination.

In the interview, Applegate revealed what she'd be doing for work after acting.

"Doing a s–ton of voice-overs to make some cash to make sure that my daughter's fed and we're homed," she said.

Applegate welcomed her now 12-year-old daughter Sadie Grace with her husband of 10 years Martyn LeNoble.

The pair were longtime friends before they married in 2013, with LeNoble supporting Applegate through her breast cancer diagnosis in 2008.

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During a 2009 interview with People, Applegate said LeNoble made her feel "beautiful" when it came to the changes in her new body.

"I'm very grateful to Martyn for coming along at a time that he did because he's been my rock through all of this," Applegate said. "He gave me something to really want to live for and something to smile about."

LeNoble is a Dutch musician and has played for bands Thelonious Monster, Too Free Stooges, Jane's Addiction and The Cult.