US Vice-President Joe Biden lands in Aust

US Vice-President Joe Biden has landed in Melbourne ahead of his three-day tour of Australia.

Mr Biden arrived with his three granddaughters on a "United States of America" jet on Saturday evening and was greeted on the tarmac by dignitaries including Federal MP Josh Frydenberg and Victorian Premier Daniel Andrews.

Mr Biden took the time to properly introduce himself and greet the nine person strong welcome party as a big media pack snapped candid photos.

US Ambassador to Australia John Berry, Victorian Governor Linda Dessau, and other US ambassadors shook hands with the vice-president.

Mr Biden is in Australia to visit Sydney and Melbourne, where Mr Biden hopes to link a cancer centre with a major US cancer research initiative.

The fight to cure cancer is an issue close to his heart, after his son Beau died of brain cancer in 2015.

Mr Biden is also booked in to watch a football match, meet with World War II veterans and meet with US company officials.

He will meet with Prime Minister Malcolm Turnbull in Sydney before indulging in some typical tourist activities.

Mr Biden left the airport in Melbourne in a 35-car motorcade heading towards the Melbourne CBD.