Three people die, including 12-year-old boy, in three separate Victorian crashes overnight

Three people have died in three separate crashes after a horror evening on Victorian roads.

A 12-year-old boy from Noble Park died in hospital after a car collided with him at the intersection of Police Road and Hansworth Street in Mulgrave just after 4.30pm yesterday.

"The driver stopped at the scene and is assisting police with their enquiries," Victoria Police said in a statement.

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Another death occurred after police said an 82-year-old man crashed into a tree on Whittlesea-Yea Road in Flowerdale about 6pm last night.

"The 82-year-old driver and sole occupant of the vehicle died at the scene," police said.

A third deadly crash occurred when police believe a motorcyclist "lost control while navigating a bend" on Wodonga-Beechworth Road in Indigo Valley about 8.26pm last night.

"CPR was performed at the scene, but the yet-to-be-identified solo rider died at the scene."

Police are appealing for information and investigating all three crashes.