Four killed after horror truck crash in in regional Victoria

Four people have been killed in a horror crash in regional Victoria this morning.

Police believe a car and B-double truck collided on the Hume Highway at the intersection of Wenkes Road in Chiltern about 10.30am.

All four people inside the sedan died at the scene.

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Wodonga Acting Senior Sergeant Joel Hughes said the car tried to turn left onto the freeway from Wenkes Road when it collided with the truck.

"It's terrible," he told media.

"Unfortunately, in regional Victoria this year we have seen a number of lives lost on our roads and this is another tragic incident.

"We are still investigating the cause of this collision, but we just want all road users to be safe on our roads."

The driver of the truck, a 30-year-old man, was rushed to Wodonga Hospital, with non-life-threatening injuries.

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Mark Parry, managing director of the driver's employer Ron Finemore Transport, said the company would help police with their investigation.

Parry said he believed the driver wasn't speeding at the time of the crash and had just come off a 12-hour break.

"He was driving less than an hour," he said

"Our thoughts are with the people who were in the vehicle and their extended family, as well as the first responders," he said.

"The people directly involved have friends, family, loved ones, and it's the flow that impacts all those people."

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Chiltern Valley is located between Wodonga and Yarrawonga, about 292km from Melbourne.

Major Collision Investigation Unit detectives are on scene, as police investigate the circumstances surrounding the crash.