Young woman dies after being pinned by bus against a building in Brisbane CBD crash

An 18-year-old woman has died after being pinned by a bus against a building in a horror crash in Brisbane's CBD.

The bus driver lost control of the vehicle and mounted a kerb in Brisbane's CBD just after 5pm, trapping the teenager against the ANZAC Square Arcade.

Emergency services rushed to the scene at the corner of Edward Street and Ann Street with paramedics attempting to treat the young woman for life-threatening injuries.

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The woman died at the scene, police said, with the forensic crash unit now investigating.

Only nine people were on the bus at the time of the crash with all passengers assessed by paramedics.

Queensland Police confirmed the woman was from the Brisbane suburb Hemmant.

"The driver of the bus and four passengers sustained minor injuries and were taken to hospital for assessment," Queensland Police said in a statement.

Queensland Ambulance Service said the driver was "suffering the effects of shock".

Nine ambulance crews attended the incident, described by Senior Sergeant Steve Watterson as a "horrendous scene".

Premier Steven Miles extended his condolences to the family on social media.

"I'm saddened to hear the news that a woman has died after a bus was involved in a serious crash in Brisbane CBD this evening," he posted on X, the platform formerly known as Twitter.

"Our thoughts go out to all those involved."

Brisbane Lord Mayor Adrian Schrinner also issued a statement following the "truly devastating incident".

"My heart goes out to everyone impacted by this tragedy," he said.

"Hearing this news has absolutely shocked me and I'm sure the entire Brisbane community will be feeling this tonight.

"None of us going about our daily lives ever expect anything like this."

The bus was towed away from the scene around 9pm local time (10pm AEDT) after significant traffic delays in the area for several hours.