'An almighty boom': Five people seriously injured after horror crash in Brisbane

Five people are in hospital with serious injuries after a horror crash in Brisbane's south-west overnight.

Initial reports suggest a Mercedes-Benz and a Toyota Landcruiser collided at the intersection of Renoir Crescent on Forest Lake Boulevard in Forest Lake about 10.10pm yesterday.

The 28-year-old male driver of the Mercedes-Benz, his two 22-year-old male passengers, and a 20-year-old female passenger were rushed to hospital with serious injuries.

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The 52-year-old female driver of the Landcruiser was also transported to hospital in a serious condition.

It's understood two remain in hospital in a critical condition while three others are now in a stable condition.

Dr Steven Rashford from Queensland Ambulance Service said extensive resources were required for the crash including five ambulances and two critical care paramedics.

"This is a very high-impact crash involving five patients," Rashford said.

"All patients suffered a combination of life-threatening injuries including internal bleeding and fractures."

The Forensic Crash Unit is investigating the circumstances behind the crash and whether speed was a factor.

One resident told 9News it was not uncommon to see cars speeding in the area.

"Coming round the corner, and then coming down here, that's a danger spot. And I don't know what the solution is," he said.

A woman said she was getting ready for bed when she heard the crash.

"Just an almighty boom, I was laying in bed almost asleep and just 'boom'," she said.