'Absolutely horrific': Boy dies after Queensland crash

A boy has died in after a "horrific" two-car crash in Queensland.

A Nissan Patrol is believed to have been travelling north along the Bruce Highway at Gregory River at about 6.40pm when it collided with a Toyota RAV4 travelling south.

A boy travelling in the Toyota died at the scene, south of Bowen.

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A 12-year-old boy who also travelling in the Toyota, was airlifted to the Mackay Base Hospital with serious injuries by the Central Queensland Helicopter Rescue Service.

"Absolutely horrific tragedy on the Bruce Highway tonight at Gregory River," the rescue service said on Facebook.

"Please send your prayers and strength to the family and friends of all those involved."

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The female driver was transported to the Proserpine Hospital.

The driver of the Nissan Patrol, a 45-year-old man, was transported to the Proserpine Hospital.

He was the only person in the Nissan.

Police are investigating the circumstances of the crash.