DFAT working 'urgently' to find out if Aussies involved in Italian train crash which left 22 dead

The Australian Department of Foreign Affairs and Trade (DFAT) says it is "making urgent enquiries" to find out if any Australians were involved in a train crash in southern Italy which killed at least 22 people and injured dozens of others.

The crash happened on a single stretch of track in countryside between the towns of Corato and Andria on Tuesday when two trains, both made up of four carriages, collided. 

An aerial image showed carriages smashed and crumpled by the force of the impact, with debris flung out amongst olive trees which flanked both sides of the track.

It is unknown if any Australians were onboard.

“The Australian Embassy in Rome is making urgent enquiries with local authorities to determine whether any Australians have been involved in the train crash in southern Italy,” a DFAT spokesperson said.

First responders at the scene worked to cut open the carriages to free passengers.

"We are working with dozens of rescue teams to open up the carriages," said Luca Cari, a fire service spokesman, adding they had saved a young boy from the wreckage.

"The rescue is complicated because this happened in the middle of the countryside," he said.

There was no immediate reason given for the collision, which took place about 11.30am local time on a hot summer's day in the region of Puglia.

"We won't stop until we get a clear explanation over what happened," Prime Minister Matteo Renzi told reporters, cutting short a visit to Milan in northern Italy to return to Rome.

A photograph handed to reporters by the fire brigade showed just four carriages left standing upright on the rails.

A fifth carriage had jumped off the tracks, while the other three units appeared pulverised.

"It looks like there has been a plane crash," said the mayor of Corato, Massimo Mazzilli.

The stretch of track is operated by a regional rail company Ferrotramviaria.

It was not clear how many people had been on the trains.

The last major rail disaster in Italy was in 2009 when a freight train derailed in Viareggio, in the centre of the country, with more than 30 people living close to the tracks killed in the subsequent fire.