Teen shot in the leg at Perth home

A 19-year-old man has been shot in the thigh at a home in Perth's northeast and the gunman remains on the loose.

Police told AAP it was believed two people who knew the victim approached the Midvale home at about 12.45pm on Tuesday.

During a dispute, the teenager was shot in the leg and was taken to Royal Perth Hospital for treatment.

Police are at the scene and have cordoned off much of Ferguson Street.

Detectives are looking for a red coloured late model Holden Monaro that was seen in the area.

Members of the public are advised not to approach the occupants but to call police immediately.