Two brothers die in South Australia crash

Two brothers have died in a head-on car crash south of Adelaide.

The siblings, aged 28 and 31, were in a van that collided with a utility on Victor Harbor Road at Mount Jagged about 4pm on Saturday.

They died at the scene, bringing the total lives lost on South Australian roads so far this year to 41.

"It's too early for me to be able to make a specific comment about the cause," Police Commissioner Grant Stevens told reporters on Sunday.

The crash had dealt a devastating blow to the family of the men, Mr Stevens said.

A 49-year-old woman from Hallet Cove who was driving the ute was airlifted to the Flinders Medical Centre with non-life-threatening injuries.

Major crash investigators are urging anyone who saw the crash or the vehicles prior to the collision to contact them.