Search for missing boy William Tyrell now in the hands of homicide squad

Homicide detectives have taken over the investigation into the disappearance of three-year-old NSW boy William Tyrell, heightening fears over his eventual fate.

William vanished from his grandparents' home in Kendall on the Mid North Coast on September 12.

However, homicide squad Detective Superintendent Michael Willing said there was no evidence yet to suggest the little boy was more likely to have been murdered, News Corp has reported.

"We want to do a thorough investigation to determine what’s happened to William and obviously we need to consider the worst case scenario," Det Supt Willing said.

"But we have no evidence to suggest any particular scenario at this stage."

William's disappearance galvanised the Kendall community, with volunteers turning up in droves to help police and emergency services in their hunt.

CCTV footage from local cameras has been examined and it has previously been reported that police checked in with all registered sex offenders living in the area, but no trace of William has yet been found.