Aussie actor calls for missing mum's safe return

Australian actor Samuel Johnson is pleading for the safe return of his missing friend Karen Ristevski who disappeared two-weeks ago.

Johnson, known for his role in TV series The Secret Life of Us described Ms Ristevski as a "sensitive, generous, intelligent and kind woman," Herald Sun reports.

"She is the last person in the world you would expect something like this to happen to ... she never puts a foot wrong. Our hearts are bleeding for her daughter," he said.

"There’s no clues, absolutely nothing. We’re mystified, we’re desperate for a result."

Police will today widen their search for the missing Melbourne mum who reportedly walked out of her Oakley Drive home after a fight with her husband Borce Ristevski.

Search crews will sweep the banks of the Maribyrnong River from Canning Reserve to Buckley Street in Avondale Heights for any clues related to her disappearance.

Mr Ristevski told police it was not usual for his wife to take a walk after an argument however she always came home soon afterwards.

Her phone was switched off after she disappeared on June 29 and her bank accounts have not been accessed.

She was last seen wearing a black jacket and jeans and was carrying $850 in a silver Coach handbag and purse.

Police have expressed concerns for the Melbourne mum's welfare and are calling on anyone who has any information about her disappearance to contact triple-0.