Reese Witherspoon pictured with three legs on Vanity Fair Hollywood cover

The cover of Vanity Fair’s 2018 Hollywood issue released yesterday features some of the biggest names in entertainment but has fallen under fire for a Photoshop fail that shows Reese Witherspoon with three legs.

The cover - which marks the 24th year of star-studded Hollywood issues - shows Ms Witherspoon sitting alongside Oprah Winfrey with her legs crossed over, however an editing mistake makes her appear to have an extra limb.

The slip-up prompted fans around the world to poke fun at Vanity Fair on social media, with Ms Witherspoon even joining in on the joke.

Behind-the-scene images have also surfaced from the cover photoshoot that appear to show Oprah with three hands.

The iconic talk show host responded to Ms Witherspoon’s tweet by also making fun of the situation.

One Twitter user also spared the time to think about the photo editors at Vanity Fair in light of the error.

“If you’re struggling at work today, just remember that you aren’t the person who let photos of Reese Witherspoon with three legs… go to print,” Christine Jackson said.

The cover also features other A-list celebrities such as Nicole Kidman, Tom Hanks, Harrison Ford and Robert De Niro all clothed in formal suits and dresses.