Multiple deaths after assailants jump out of SUV and fire into crowd at Florida club

Police are looking for the assailants who opened fire on a Florida club, killing at least two people and wounding at least 20 more, Miami-Dade police director Alfredo Ramirez III says.

A white Nissan Pathfinder pulled up to a billiards club in Hialeah, a city in Miami-Dade County between 12am and 1am (3-4pm AEST).

Three people got out with assault weapons and handguns and started firing into the crowd that was gathered for a concert at the venue, Mr Ramirez said.

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He said two people were pronounced dead at the scene, and 20 to 25 victims were at various nearby hospitals.

Police said at least one of those hospitalised is in critical condition.

"These are cold-blooded murderers that shot indiscriminately into a crowd and we will seek justice," Mr Ramirez tweeted.

"My deepest condolences to the family of the victims."

The Miami-Dade Police Department is asking anyone with information about the shooters or their whereabouts to contact authorities.