West Ham's Ayew out of EPL for four months

West Ham's record signing Andre Ayew is out of the English Premier League for four months with a thigh injury.

Club chairman David Gold tweeted Thursday: "Sad news. Ayew has injured his quadriceps and will need surgery. He will be out for 4 months. Good luck Andre".

Ayew was injured 35 minutes into his debut in West Ham's 2-1 defeat on Monday at Chelsea.

The 26-year-old Ghana forward signed for West Ham on August 8 for a club record of STG20.5 million ($A35 million).

Ayew, who joined on a three-year deal with the option of two more years, played alongside current West Ham star Dimitri Payet at Marseille.