Sydney's M4 Motorway reopened after serious accident involving car and truck

All lanes on the M4 Motorway have been reopened after a serious accident involving a car and truck in Homebush blocked traffic and caused major delays in peak hour.

The Transport Management Centre has advised motorists to consider delaying citybound travel this morning on the M4, where traffic is currently queued for 15km.

Significant delays are also being experienced on roads surrounding the M4 including Parramatta Road and Silverwater Road.

Buses are also delayed up to 45 minutes between Prospect and Strathfield.

Download the 9NEWS Alerts app for iPhone or Android to get push notifications when a major story breaks near your location.