Pauline Hanson already facing opposition as political comeback beckons

Pauline Hanson is set to return to parliament as a Queensland senator, but is being warned she will have to be on her best behaviour.

The One Nation founder will almost certainly take one of the 12 Queensland Senate seats available, and her party could yet win others in that state, WA and NSW.

Ms Hanson was first elected to federal parliament as a lower house MP in the seat of Oxley in 1996, but was defeated in 1998.

Last year, she lost a run for a Queensland state government seat – the 12th campaign of her colourful and controversial career.

Queensland premier Annastacia Palaszczuk said Ms Hanson and other incoming senators should be responsible and not put important state issues like exports and tourism at risk.

"My message to all the senators is you must stand up for Queensland but you must act responsibly,' she said.

Greens leader Richard Di Natale has vowed to fight against what he termed as Ms Hanson's "racist and bigoted agenda".

"We will take it right up to her, to show that in a modern Australia there is no place for racism, there is no place for bigotry, for the sort of hatred that she is spreading through her views," Senator Di Natale said in Melbourne today.

"We won't roll over like (former prime minister) John Howard did when Pauline Hanson first came on to the political scene federally."

Ms Hanson declined to speak to the media today, but spoke to the 9NEWS election panel while the votes were still being counted, telling them “I know what the people are thinking and how they’re feeling, so let's get this country on track.”

Ms Hanson said she had no problems working with any parties.

"If they have got a problem with me, that's their issue, not mine," she said.

"I've got 20 years' experience in politics and I believe that we need maturity in the parliament to start passing legislation that is right for the people and our future generations."