Two people found dead after suspicious fire at Adelaide home

An Adelaide house fire is at the centre of a murder-suicide investigation.

Firefighters and police found the house on Emerald Street in Edwardstown "well alight" when they arrived just after 5am today after receiving calls from neighbours, according to police.

The bodies of Sally Davis and her mother, Trish, were found inside a room in the middle of the house.

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Detectives are investigating whether it was a murder-suicide.

Police refused to confirm Davis stabbed her mother before setting the room on fire.

"We are not ruling out anyone else being involved because we are so early in the investigation," detective chief inspector Kieran Baggoley said.

"However we are focused at this stage on the two occupants that were in the address."

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Davis's mother lived with a disability and 9News understands Davis cared for her.

The home is owned by disability housing group Your Place, which is now assisting police.

Neighbours said they barely saw the pair and they felt shaken by the fire.

"I feel bad for the people who lost someone in the fire... it's horrible," neighbour Maria Roberts said.

"I have seen them, I have said hello to them passing as I was walking but I didn't know them. It is concerning, very much," another neighbour Olga Aginartzis said.

Police sifted through the home today and seized several items.

Major crime detectives are now leading the investigation and a post-mortem is being carried out.

Crisis support is available from Lifeline on 13 11 14.

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