Teens fighting for their lives after Brisbane house fire

Two teenagers are fighting for life after being left severely burned in a house fire in Brisbane's north.

The 16-year-old girls suffered severe burns to large parts of their body in the blaze at a property in Carseldine overnight.

Another two people are in hospital with serious injuries.

"At this stage it's still too early, with the amount of damage inside, to properly assess what could have possibly caused it," Queensland Fire and Emergency Services Mark Millanta said.

The home has been destroyed in the fire and is likely to be demolished.